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Comorbid Conditions and Gout

Arthritis Foundation

In gout, uric acid builds up and forms painful crystals around joints, often affecting the big toe. Health problems linked to gout go beyond the joints, however. Excess uric acid can also damage kidneys, blood vessels, and other organs, and gout raises the risk for several disorders. These include kidney and cardiovascular disease, as well as diabetes, depression and sleep apnea.